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Nutrition Reviews

Head to head · Vitamins & Minerals

NatureWise Vitamin D3 5000 IU Softgels vs Tru Niagen Nicotinamide Riboside 300 mg

NatureWise scores higher overall (8.5 vs 6.6 out of 10), mainly on efficacy, value, experience and transparency. Tru Niagen still leads on quality & purity.

Updated November 2026 from our full reviews · How we score

Higher score
Front of the NatureWise Vitamin D3 125 mcg (5,000 IU) 360-softgel bottle with one mini softgel
NatureWiseVitamin D3 5000 IU Softgels
8.5
Excellent

An NSF-certified vitamin D3 mini softgel in olive oil for about 4 cents a day, but its 5,000 IU dose exceeds the 4,000 IU adult upper limit.

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Front of the Tru Niagen 300 mg bottle of 30 vegetarian capsules
Tru NiagenNicotinamide Riboside 300 mg
6.6
Mixed

A rigorously tested nicotinamide riboside capsule that reliably raises NAD+, though trials in healthy adults show few clear health benefits for $1.63 a day.

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The short answer

Choose NatureWise if…

  • Adults whose clinician has confirmed low vitamin D and recommends 5,000 IU
  • Budget shoppers who want an independently certified vitamin D3
  • People who find large pills hard to swallow
  • You care most about efficacy, value, experience, transparency
  • You want the lower cost per serving ($0.04)

Choose Tru Niagen if…

  • Adults who want the most-studied, NSF-certified form of nicotinamide riboside
  • People curious about NAD+ who accept that the benefits are unproven
  • Drug-tested athletes who need a certified product
  • You care most about quality & purity

Key differences

Biggest scoring gap
Value: NatureWise 9.7, Tru Niagen 4.5. This factor covers cost per effective serving compared with category peers.
Price
NatureWise costs $0.04 a serving, 98% less than Tru Niagen ($1.63): about $1.20 versus $48.90 for 30 servings at the list prices in our reviews.
Independent testing
NatureWise carries NSF Contents Certified; Tru Niagen carries NSF Certified for Sport.
Formula
Of the key ingredients in our reviews, only NatureWise lists vitamin D, and only Tru Niagen lists magnesium.
Format
NatureWise: softgel, 360 servings per container; Tru Niagen: capsule, 30 servings per container.
Dietary labels
Only NatureWise is labeled dairy-free, soy-free and non-GMO. Only Tru Niagen is labeled vegetarian.

Side by side

Vitamin D3 5000 IU SoftgelsNicotinamide Riboside 300 mg
Our score8.5 / 106.6 / 10
Efficacy (30%)7.45.5
Quality & Purity (25%)8.79.0
Value (20%)9.74.5
Experience (15%)8.87.5
Transparency (10%)8.26.5
FormSoftgelCapsule
Serving1 Softgel360 servings per container1 vegetarian capsule30 servings per container
Price per serving$0.04$1.63
Testing & certifications
NSF Contents CertifiedcGMP facility
NSF Certified for SportKosherHalalcGMP facility
DietaryGluten-free, Dairy-free, Soy-free, Non-GMOVegetarian, Gluten-free
Key ingredients
  • Vitamin D3 (as cholecalciferol)125 mcg (5,000 IU)
  • Organic extra virgin olive oil
  • Softgel capsule (halal gelatin, glycerin, purified water)
  • Niagen (nicotinamide riboside chloride)300 mg
  • Microcrystalline cellulose, hypromellose capsule, vegetable magnesium stearateNot disclosed
Flavors——
Creator video reviews54

Pros and cons

Vitamin D3 5000 IU Softgels

  • NSF Contents Certified, confirmed in NSF's public listings
  • About 4 cents a day for a year's supply at the brand's list price
  • Very small softgels that buyers describe as tasteless and easy to swallow
  • 5,000 IU exceeds the 4,000 IU adult upper limit for daily use
  • Softgels can fuse together when shipped or stored in heat
All 7 pros and cons

Nicotinamide Riboside 300 mg

  • NSF Certified for Sport and third-party tested by Alkemist Labs
  • 300 mg raised blood NAD+ about 51% in a controlled trial
  • Single patented ingredient with an FDA GRAS letter and two NDI notifications
  • Trials in healthy adults show few consistent health benefits
  • Marketing leans on a six-person NMN comparison and broad "cellular energy" language
All 8 pros and cons

Our verdict: NatureWise vs Tru Niagen

NatureWise is the stronger product overall, 8.5 to 6.6 in our scoring, ahead on efficacy, value, experience and transparency. It is also 98% cheaper per serving. If you are tested for banned substances, choose Tru Niagen: it is the one with NSF Certified for Sport. Each full review shows the evidence, testing and buyer feedback behind these scores.

Full Vitamin D3 5000 IU Softgels review Full Nicotinamide Riboside 300 mg review

What creators say

Questions people ask

Is NatureWise better than Tru Niagen?
In our scoring, NatureWise Vitamin D3 5000 IU Softgels rates higher overall (8.5 vs 6.6 out of 10). NatureWise leads on efficacy, value, experience and transparency; Tru Niagen leads on quality & purity. Scores weigh efficacy, quality, value, experience and transparency.
Which is cheaper per serving, NatureWise or Tru Niagen?
NatureWise costs about $0.04 per serving versus $1.63 for Tru Niagen, based on the list prices shown in our reviews. Prices change often, so check the current price before buying.
Are NatureWise and Tru Niagen third-party tested?
NatureWise carries NSF Contents Certified; Tru Niagen carries NSF Certified for Sport. Sport-level certifications screen for banned substances, which matters for drug-tested athletes.
Who should choose NatureWise over Tru Niagen?
Our reviews suggest NatureWise is best for adults whose clinician has confirmed low vitamin D and recommends 5,000 IU, budget shoppers who want an independently certified vitamin D3 and people who find large pills hard to swallow, while Tru Niagen is best for adults who want the most-studied, NSF-certified form of nicotinamide riboside, people curious about NAD+ who accept that the benefits are unproven and drug-tested athletes who need a certified product.
What is the difference between NatureWise and Tru Niagen?
NatureWise costs $0.04 a serving, 98% less than Tru Niagen ($1.63): about $1.20 versus $48.90 for 30 servings at the list prices in our reviews. NatureWise carries NSF Contents Certified; Tru Niagen carries NSF Certified for Sport. Of the key ingredients in our reviews, only NatureWise lists vitamin D, and only Tru Niagen lists magnesium.

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