Nicotinamide Riboside 300 mg

Tru Niagen 300 mg is one vegetarian capsule of Niagen, the patented nicotinamide riboside chloride (NR) made by Niagen Bioscience, the Los Angeles company called ChromaDex until March 2025. NR is a form of vitamin B3 that the body turns into NAD+, a coenzyme used in energy metabolism and DNA repair whose levels fall with age. Each capsule supplies about 263 mg of NR itself. The NAD+ rise is well documented: in a company-funded eight-week trial, 300 mg a day lifted blood NAD+ about 51% within two weeks, and independent studies confirm the effect.

Whether more NAD+ makes healthy people healthier is much less clear. Trials in middle-aged, older and overweight adults, mostly at 1,000 to 2,000 mg a day, found no consistent gains in insulin sensitivity, mitochondrial function, blood pressure or muscle, and a 2026 systematic review called the anti-aging evidence inconclusive. "Age Better" and "cellular energy" describe the NAD+ effect, not proven outcomes. The brand's 161% versus 69% win over NMN comes from a six-person, eight-day study at 1,200 mg a day; a 65-person trial found the two raised NAD+ comparably.

Quality is excellent. The capsules are NSF Certified for Sport, kosher and halal, the brand says each product is tested by Alkemist Labs, and NR holds an FDA GRAS "no questions" letter plus two new dietary ingredient notifications. FDA, which had barred rival NMN from supplements, reversed itself in September 2025. Controlled trials of up to 2,000 mg a day for 12 weeks found no safety problems, but longer-term data are thin. The label says it is not for anyone under 18 and to ask a clinician if pregnant, nursing or on medication. At $49 for 30 capsules ($1.63 a day, $1.31 on subscription) it is mid-priced, though trial doses mean three or more capsules daily.