Skip to content
Nutrition Reviews

Head to head · Gut Health & Probiotics

Physician's Choice 60 Billion Probiotic vs Physician's Choice Digestive Enzymes

60 Billion Probiotic scores higher overall (7.2 vs 5.7 out of 10) and leads on all five factors we score.

Updated October 2026 from our full reviews · How we score

Higher score

Amazon's mega-seller: 60 billion CFU from 10 species plus prebiotic fiber, third-party tested and cheap. But it names no strains, so it can't be matched to research.

Check price on AmazonBuy from the brand

We may earn a commission when you buy through these links — it never affects our scores. How we make money

Read the full review

A viral one-a-day blend of 16 enzymes and spore probiotics, but its three proprietary blends list no enzyme activity units, so potency can't be judged.

Check price on AmazonShop on TikTok Shop595.1K sold

We may earn a commission when you buy through these links — it never affects our scores. How we make money

Read the full review

We may earn a commission when you buy through these links — it never affects our scores. How we make money

The short answer

Choose 60 Billion Probiotic if…

  • Shoppers who want an inexpensive multi-strain probiotic
  • People who value third-party testing
  • Simple once-daily routines
  • You care most about efficacy, quality & purity, value, experience, transparency

Choose Digestive Enzymes if…

  • Budget shoppers who want to try a broad enzyme blend with meals
  • People who have already found it helps after heavy meals
  • Anyone who prefers a simple one-capsule routine

Side by side

60 Billion ProbioticDigestive Enzymes
Our score7.2 / 105.7 / 10
Efficacy (30%)6.04.2
Quality & Purity (25%)7.86.8
Value (20%)8.26.8
Experience (15%)8.47.1
Transparency (10%)5.03.5
FormCapsuleCapsule
Serving1 capsule30 servings per container1 Capsule60 servings per container
Price per servingSee retailer$0.40
Testing & certifications
Non-GMO Project VerifiedThird-party testedcGMP facility
Third-party testedcGMP facility
DietaryVegan, Vegetarian, Gluten-free, Dairy-free, Soy-free, Non-GMOVegan, Vegetarian, Dairy-free, Soy-free, Non-GMO
Key ingredients
  • Probiotic Blend (10 species)220 mg / 60 billion CFU
  • Organic Prebiotic Blend150 mg
  • Digestive Enzyme Blend (16 enzymes)85 mg (blend total)
  • Bacillus subtilis OPTIBIOME BS50
  • Bacillus coagulans and Bacillus clausii
  • Prebiotic fibers (organic Jerusalem artichoke inulin, organic acacia, chicory inulin)
  • Herbal Blend (peppermint leaf, ginger root)150 mg (blend total)
Flavors——
Creator video reviews25

Pros and cons

60 Billion Probiotic

  • The brand guarantees 60 billion CFU through expiration, not just at manufacture
  • Third-party tested (the brand names Eurofins and Light Labs) and Non-GMO Project Verified
  • About 60–83 cents a day, depending on bottle size
  • Once-daily, shelf-stable, acid-resistant capsule
  • No strain designations, so the formula can't be matched to clinical trials
  • Proprietary blend: one total for 10 species, with no per-strain amounts
  • The inulin prebiotic may cause gas in FODMAP-sensitive people
  • Made in a facility that also processes major allergens

Digestive Enzymes

  • About 40 cents a day for the 60-count bottle, less with larger sizes or a subscription
  • Includes Bacillus subtilis BS50, a branded strain with a published human trial on gas-related symptoms
  • Covers enzymes for protein, starch, fat, dairy sugar and bean sugars in one vegan capsule
  • Buyers frequently report less post-meal heaviness and find the capsule easy to swallow
  • Brand states lot testing at ISO 17025-accredited labs and cGMP manufacturing
  • Three proprietary blends with no enzyme activity units, so potency can't be compared or verified
  • The 2 billion CFU claim appears only on the front label, and two of the three strains lack strain designations
  • Prebiotic and herbal amounts are tiny, and one capsule covers only one meal
  • Some buyers report diarrhea or no clear benefit, and no certificates of analysis are published

Our verdicts

60 Billion Probiotic

This is a well-made, well-priced, third-party-tested daily probiotic, which explains its popularity. But without strain designations or per-strain doses, you're buying a high CFU count rather than a formula matched to clinical research. It's a reasonable budget multi-strain option, not an evidence-based pick for a specific goal.

Full review

Digestive Enzymes

This is an inexpensive, easy one-capsule habit that many buyers like, and the BS50 probiotic strain has some research behind it. But three proprietary blends, no enzyme activity units and a CFU count printed only on the front make it impossible to tell whether any ingredient is present at a meaningful dose. If dairy or beans are your trigger, a dosed lactase or alpha-galactosidase product is the more targeted buy, and bloating that persists deserves a medical evaluation.

Full review

What creators say

Questions people ask

Is 60 Billion Probiotic better than Digestive Enzymes?
In our scoring, Physician's Choice 60 Billion Probiotic rates higher overall (7.2 vs 5.7 out of 10). 60 Billion Probiotic leads on efficacy, quality & purity, value, experience and transparency. Scores weigh efficacy, quality, value, experience and transparency.
Who should choose 60 Billion Probiotic over Digestive Enzymes?
Our reviews suggest 60 Billion Probiotic is best for shoppers who want an inexpensive multi-strain probiotic, people who value third-party testing and simple once-daily routines, while Digestive Enzymes is best for budget shoppers who want to try a broad enzyme blend with meals, people who have already found it helps after heavy meals and anyone who prefers a simple one-capsule routine.

More gut health & probiotics comparisons