Best Overall
8.3Good
Classic psyllium fiber with some of the strongest evidence in the aisle for regularity and LDL cholesterol, at about 19 cents a teaspoon. Contains aspartame and dye.
3 videosGut Health & Probiotics
Physician's Choice Trending on TikTok
Digestive Enzymes
A viral one-a-day blend of 16 enzymes and spore probiotics, but its three proprietary blends list no enzyme activity units, so potency can't be judged.
5.7
Poor
Nutrition Reviews score
Weighted across efficacy, quality, value, experience & transparency. See breakdown
- Form
- Capsule
- Serving
- 1 Capsule
- Servings
- 60
- Per serving
- $0.40
Third-party testedcGMP facility
VeganVegetarianDairy-freeSoy-freeNon-GMO
Check price on AmazonShop on TikTok Shop595.1K soldBuy from the brand$23.95
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Last reviewed October 21, 2026 by the Nutrition Reviews Editorial Team · How we review
Our verdict
This is an inexpensive, easy one-capsule habit that many buyers like, and the BS50 probiotic strain has some research behind it. But three proprietary blends, no enzyme activity units and a CFU count printed only on the front make it impossible to tell whether any ingredient is present at a meaningful dose. If dairy or beans are your trigger, a dosed lactase or alpha-galactosidase product is the more targeted buy, and bloating that persists deserves a medical evaluation.
Best for
- Budget shoppers who want to try a broad enzyme blend with meals
- People who have already found it helps after heavy meals
- Anyone who prefers a simple one-capsule routine
Skip it if
- People with diagnosed pancreatic insufficiency, who typically need prescription enzyme therapy
- Shoppers who want disclosed enzyme activity and probiotic doses
- Anyone allergic to pineapple or papaya (contains bromelain and papain)
How it scored
Our five-factor score out of 10. Factors are weighted by how much they matter to the outcome you’re paying for. Methodology
5.7
Poorout of 10
- Efficacy30%4.2
Key ingredients at clinically studied doses, and how strong the evidence is.
- Quality & Purity25%6.8
Third-party testing and certifications, manufacturing standards, contaminant testing, recall history.
- Value20%6.8
Cost per effective serving compared with category peers.
- Experience15%7.1
Taste, mixability, texture and tolerability from aggregated buyer and creator feedback.
- Transparency10%3.5
Full label disclosure (no proprietary blends), available COAs, honest marketing.
Our review
Physician's Choice Digestive Enzymes is among the brand's top sellers on TikTok Shop, where viral videos show a capsule turning pudding into liquid. Each daily capsule combines an 85 mg blend of 16 enzymes, including amylase, several proteases, lipase, lactase and alpha-galactosidase; a 159 mg blend of prebiotic fibers and three Bacillus probiotics; and 150 mg of peppermint leaf and ginger root. The pudding demo shows enzymes breaking down the starch that thickens pudding in a cup. It says little about bloating in a person, or about how much enzyme each capsule holds.
That dose question is the core problem. The label gives blend weights, not the activity units, such as HUT for protease or ALU for lactase, that make enzyme products comparable, and no ingredient is dosed individually. The front promises 2 billion CFU, a figure missing from the Supplement Facts panel, and only one strain, Bacillus subtilis BS50, is identified. In a six-week trial of 76 healthy adults funded by its maker, 2 billion CFU of BS50 a day eased gas-related symptoms; here it shares that total with two other strains. Evidence for broad enzyme blends in people without a diagnosed deficiency is thin, and a Johns Hopkins dietitian says healthy people generally don't need them. Lactase for dairy and alpha-galactosidase for beans have clearer uses, at doses this label doesn't reveal.
The brand says every lot is tested at ISO 17025-accredited labs and made in a cGMP-certified US facility, but it publishes no certificates of analysis. Buyers frequently report less heaviness and bloating after meals and an easy-to-swallow capsule, while a minority report diarrhea or stomach upset and some question the value. At $23.95 for 60 capsules, one a day costs about 40 cents.
What’s inside
| Key ingredient | Per serving | Why it matters |
|---|---|---|
| Digestive Enzyme Blend (16 enzymes) Includes amylase, glucoamylase, several proteases, lipase, lactase and alpha-galactosidase, but no activity units or per-enzyme amounts are listed, so potency can't be compared with studied products. | 85 mg (blend total) | Includes amylase, glucoamylase, several proteases, lipase, lactase and alpha-galactosidase, but no activity units or per-enzyme amounts are listed, so potency can't be compared with studied products. |
| Bacillus subtilis OPTIBIOME BS50 Branded spore strain; a maker-funded six-week trial in 76 healthy adults found fewer gas-related symptoms at 2 billion CFU a day. Its dose here isn't disclosed. | — | Branded spore strain; a maker-funded six-week trial in 76 healthy adults found fewer gas-related symptoms at 2 billion CFU a day. Its dose here isn't disclosed. |
| Bacillus coagulans and Bacillus clausii Spore-forming probiotics listed without strain designations, so they can't be matched to clinical research. | — | Spore-forming probiotics listed without strain designations, so they can't be matched to clinical research. |
| Prebiotic fibers (organic Jerusalem artichoke inulin, organic acacia, chicory inulin) Share a 159 mg blend with the probiotics, a tiny amount next to the grams of fiber used in prebiotic research. | — | Share a 159 mg blend with the probiotics, a tiny amount next to the grams of fiber used in prebiotic research. |
| Herbal Blend (peppermint leaf, ginger root) Small amounts; NIH notes peppermint leaf itself has very little research, and enteric-coated peppermint oil is the form studied for IBS. | 150 mg (blend total) | Small amounts; NIH notes peppermint leaf itself has very little research, and enteric-coated peppermint oil is the form studied for IBS. |
Supplement Facts
Serving Size 1 Capsule
Servings Per Container 60
Amount Per Serving% Daily Value
Prebiotic and Probiotic Blend 159 mg†
Organic Inulin (from Jerusalem Artichoke), Organic Acacia Fiber, Inulin (from Chicory), Bacillus subtilis OPTIBIOME BS50™, Bacillus coagulans, Bacillus clausii
Herbal Blend 150 mg†
Peppermint Leaf, Ginger Root
Digestive Enzyme Blend 85 mg†
Bromelain, Amylase, Protease 4.5, Glucoamylase, Protease 6.0, Papain, Lactase, Protease 3.0, Peptidase, Cellulase, Beta-Glucanase, Alpha-Galactosidase, Lipase, Xylanase, Hemicellulase, Invertase
* Percent Daily Values are based on a 2,000 calorie diet. † Daily Value not established.
Other ingredients: Vegetable capsule (hypromellose), rice flour, rice hull concentrate, gum arabic, and sunflower oil.
Manufactured in a facility that also processes dairy, soy, gluten, wheat, tree nuts, peanuts, eggs, fish, shellfish, and sesame.
Testing & quality
Physician's Choice says independent labs, including Eurofins and Light Labs, test its products for purity, potency and contaminants, and that they're made in cGMP-certified U.S. facilities. It also says probiotic CFU counts are guaranteed through expiration.
Goals it supports
Creator video reviews
Independent creators reviewing Digestive Enzymes on YouTube and TikTok.
4 positive1 mixed0 critical
Pros & cons
What we like
- About 40 cents a day for the 60-count bottle, less with larger sizes or a subscription
- Includes Bacillus subtilis BS50, a branded strain with a published human trial on gas-related symptoms
- Covers enzymes for protein, starch, fat, dairy sugar and bean sugars in one vegan capsule
- Buyers frequently report less post-meal heaviness and find the capsule easy to swallow
- Brand states lot testing at ISO 17025-accredited labs and cGMP manufacturing
Watch-outs
- Three proprietary blends with no enzyme activity units, so potency can't be compared or verified
- The 2 billion CFU claim appears only on the front label, and two of the three strains lack strain designations
- Prebiotic and herbal amounts are tiny, and one capsule covers only one meal
- Some buyers report diarrhea or no clear benefit, and no certificates of analysis are published
Questions buyers ask
How strong are the enzymes in Physician's Choice Digestive Enzymes?
The label doesn't say. It lists 16 enzymes in an 85 mg blend by weight, without the activity units, such as HUT for protease or ALU for lactase, that measure how much work an enzyme can do. Without those numbers, or amounts for each enzyme, you can't compare it with other products or with the doses used in research.
Do healthy people need digestive enzyme supplements?
Usually not. The pancreas and small intestine make the enzymes needed for a normal diet, and a Johns Hopkins dietitian says healthy people generally don't need supplements. Evidence for broad enzyme blends in people without a diagnosed deficiency comes from a few small, mostly industry-funded trials. Targeted enzymes are different: lactase for dairy and alpha-galactosidase for beans have clearer uses.
How should I take it, and is one capsule enough?
The label directs one capsule with your largest meal, and enzymes act only on the food they're taken with, so other meals get no help. The brand says many people take a second capsule with another heavy meal and advises checking with a clinician before regularly taking more than two. Ongoing bloating, pain, weight loss or diarrhea calls for a medical evaluation rather than more capsules.
Sources we checked (19)
- 1.physicianschoice.com/products/digestive-enzymes-prebiotic-probiotic
- 2.physicianschoice.com/products/digestive-enzymes-prebiotic-probiotic.js
- 3.cdn.shopify.com/s/files/1/2677/6462/files/DIG-60CT-CAROUSEL_6_3.7.0_3dc88076-3555-4d9
- 4.cdn.shopify.com/s/files/1/2677/6462/files/250224_DIG_60CT_3DRender_3.7.0.png?v=175045
- 5.physicianschoice.com/pages/about
- 6.physicianschoice.com/pages/quality-standards-and-testing
- 7.physicianschoice.com/policies/terms-of-service
- 8.amazon.com/dp/B0C21ZLQNC
- 9.shop.tiktok.com/us/pdp/digestive-enzymes-by-physicians-choice-with-probiotics-prebiot
- 10.shop.tiktok.com/us/store/physicians-choice/7495112601529781234
- 11.finance.yahoo.com/media-advertising/articles/supplement-brands-doing-big-business-04010
- 12.hopkinsmedicine.org/health/wellness-and-prevention/digestive-enzymes-and-digestive-enzyme
- 13.pubmed.ncbi.nlm.nih.gov/26806042/
- 14.pubmed.ncbi.nlm.nih.gov/36269141/
- 15.pubmed.ncbi.nlm.nih.gov/37976892/
- 16.pubmed.ncbi.nlm.nih.gov/30156436/
- 17.pubmed.ncbi.nlm.nih.gov/7964541/
- 18.nccih.nih.gov/health/peppermint-oil
- 19.info.nsf.org/Certified/Dietary/Listings.asp?CompanyName=physician&Standard=173
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