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Front of Thorne Iron Bisglycinate 60-capsule bottle

Iron Bisglycinate

25 mg of chelated iron (Ferrochel bisglycinate) in a small, NSF Certified for Sport capsule; gentler than iron salts for most, but only for people who need iron.

8.6

Excellent

Nutrition Reviews score

Weighted across efficacy, quality, value, experience & transparency. See breakdown

Form
Capsule
Serving
1 capsule
Servings
60
Videos
5
NSF Certified for Sport
Gluten-freeDairy-freeSoy-free
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Last reviewed September 29, 2026 by the Nutrition Reviews Editorial Team · How we review

Our verdict

If you have documented low iron and struggle with conventional iron pills, this is one of the best-tolerated and best-verified options available, at a fair premium. It is not something to take without a reason: check ferritin first, and space it from calcium, thyroid medication and zinc.

Best for

  • People with low ferritin who get stomach upset from ferrous sulfate
  • Menstruating women and athletes who need iron under medical guidance
  • Vegetarians with confirmed low iron

Skip it if

  • Anyone without a confirmed need for iron
  • People with hereditary hemochromatosis
  • Homes with young children, unless stored securely

How it scored

Our five-factor score out of 10. Factors are weighted by how much they matter to the outcome you’re paying for. Methodology

8.6
Excellent

out of 10

  • Efficacy30%8.5

    Key ingredients at clinically studied doses, and how strong the evidence is.

  • Quality & Purity25%9.3

    Third-party testing and certifications, manufacturing standards, contaminant testing, recall history.

  • Value20%7.6

    Cost per effective serving compared with category peers.

  • Experience15%8.6

    Taste, mixability, texture and tolerability from aggregated buyer and creator feedback.

  • Transparency10%9.0

    Full label disclosure (no proprietary blends), available COAs, honest marketing.

Our review

Thorne Iron Bisglycinate is the iron supplement people tend to reach for after cheaper iron upset their stomach. Each small capsule supplies 25 mg of elemental iron (139% of the Daily Value) as Ferrochel ferrous bisglycinate chelate, with only a cellulose capsule, microcrystalline cellulose, leucine and silicon dioxide alongside. It is NSF Certified for Sport, gluten-, dairy- and soy-free, and ranks among Amazon's top iron supplements with nearly 9,000 ratings.

The form is the selling point. NIH notes that iron amino-acid chelates might cause fewer gastrointestinal side effects than ferrous or ferric salts, and that supplemental iron at 45 mg a day or more commonly causes nausea and constipation. One capsule stays below that 45 mg adult upper limit. Buyers and creators consistently describe it as easier on the stomach than iron they tried before, although a minority still report nausea, especially on an empty stomach.

Iron supplements are for people who need them. Women aged 19 to 50 need 18 mg a day and adult men only 8 mg, and people with hereditary hemochromatosis should avoid iron supplements, so a blood test that includes ferritin is the right starting point. Take it apart from calcium and at least four hours away from levothyroxine; acid-reducing drugs can lower iron absorption, and iron doses of 25 mg or more can reduce zinc absorption.

At $16 for 60 capsules (about 27 cents a day), it costs more than generic ferrous sulfate, which is the main point reviewers debate. Store it securely: accidental iron overdose is a leading cause of fatal poisoning in children under six.

What’s inside

Key ingredientPer serving
Iron (as Ferrochel ferrous bisglycinate chelate)

139% DV; below the 45 mg adult upper limit, and an amino-acid chelate that may be gentler than iron salts.

25 mg

Supplement Facts

Serving Size One Capsule

Amount Per Serving% Daily Value
Iron (as Ferrochel® Ferrous Bisglycinate Chelate) 25 mg139%

* Percent Daily Values are based on a 2,000 calorie diet. † Daily Value not established.

Other ingredients: Hypromellose (derived from cellulose) capsule, microcrystalline cellulose, leucine, silicon dioxide.

Transcribed from the manufacturer’s label (vitacost.com). Formulas change — always check the label on the product you buy.

Testing & quality

Many products are NSF Certified for Sport (listed in NSF's database); others carry NSF Contents Certified status. Thorne states it tests ingredients and finished products for identity, purity, potency and contaminants.

Creator video reviews

Independent creators reviewing Iron Bisglycinate on TikTok and YouTube.

3 positive1 mixed1 critical

Pros & cons

What we like

  • Iron amino-acid chelate, a form NIH says may cause fewer GI side effects
  • NSF Certified for Sport
  • 25 mg dose sits below the 45 mg upper limit
  • Small 18 mm capsule with a short ingredient list

Watch-outs

  • About $0.27 per day, more than generic ferrous sulfate
  • Some users still report nausea on an empty stomach
  • No vitamin C or other cofactors included
  • Not appropriate without a confirmed need for iron

Questions buyers ask

Should I take Thorne Iron Bisglycinate on an empty stomach?
Iron is often taken on an empty stomach for absorption, but that is also when nausea is most likely, and some users report exactly that. If the capsule upsets your stomach, taking it with a small meal is a reasonable trade-off. Keep it apart from calcium supplements, which can reduce iron absorption, and follow your clinician's plan if you are treating a deficiency.
How is iron bisglycinate different from ferrous sulfate?
Ferrous sulfate is an inexpensive iron salt that is widely used but commonly causes GI side effects at higher doses. Iron bisglycinate is iron bound to the amino acid glycine, and NIH notes that iron amino-acid chelates might cause fewer gastrointestinal side effects than ferrous or ferric salts. Compare products by elemental iron: this capsule provides 25 mg.
Can I take it with other supplements or medicines?
Separate it from calcium supplements and take it at least four hours apart from levothyroxine. Proton pump inhibitors can reduce iron absorption, and iron doses of 25 mg or more can lower zinc absorption, so space it from a zinc supplement. People with hereditary hemochromatosis should not take iron supplements.
Sources we checked (10)
  1. 1.thorne.com/products/dp/iron-bisglycinate
  2. 2.vitacost.com/products/thorne-iron-bisglycinate-60-capsules-25-mg-per-capsule-52838
  3. 3.amazon.com/dp/B0797GZDZL
  4. 4.info.nsf.org/Certified/Dietary/Listings.asp?CompanyName=Thorne
  5. 5.ods.od.nih.gov/factsheets/Iron-HealthProfessional/
  6. 6.youtube.com/watch?v=tBl8FsH9GKM
  7. 7.youtube.com/watch?v=PDkohwjab7M
  8. 8.youtube.com/watch?v=NcyEFZxUVU4
  9. 9.tiktok.com/@annie.bao/video/7620279527171771678
  10. 10.tiktok.com/@_eliananana/video/7355593814968454442

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Nutrition Reviews Editorial Team · Sep 28, 2026