Best Value
Nature's Bounty
Vitamin B-12 1,000 mcg
8.5Excellent
A best-selling 1,000 mcg cyanocobalamin tablet at about 5 cents a day; small and easy to swallow, with no third-party seal.
1 videoVitamins & Minerals
Ultra CoQ10 100 mg Softgels
Once-daily 100 mg ubiquinone in a water-and-fat-soluble base at a fair price, though CoQ10's evidence for statin aches and blood pressure is weak.
7.1
Mixed
Nutrition Reviews score
Weighted across efficacy, quality, value, experience & transparency. See breakdown
- Form
- Softgel
- Serving
- 1 Softgel
- Servings
- 90
- Per serving
- $0.29
Third-party testedcGMP facility
Gluten-free
Check price on AmazonShop on TikTok Shop38 soldBuy from the brand$25.99
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Last reviewed October 22, 2026 by the Nutrition Reviews Editorial Team · How we review
Our verdict
Qunol Ultra is a well-made, inexpensive way to take 100 mg of CoQ10 once a day, and solubilized formulas like this one generally absorb better than plain powdered CoQ10. The weak link is CoQ10 itself: evidence is mixed for statin aches and negative for blood pressure, and the heart-failure and migraine trials used 300 mg a day. Take it with food, and talk to your clinician first if you use warfarin or insulin.
Best for
- Statin users who want to try CoQ10 for muscle aches with their doctor's agreement
- People who want a simple, once-daily ubiquinone softgel
- Budget-minded buyers (about $0.29 a day at the brand's price)
Skip it if
- Vegetarians and vegans (bovine gelatin softgel)
- People expecting lower blood pressure or a noticeable energy boost
- Warfarin or insulin users without medical supervision
How it scored
Our five-factor score out of 10. Factors are weighted by how much they matter to the outcome you’re paying for. Methodology
7.1
Mixedout of 10
- Efficacy30%6.2
Key ingredients at clinically studied doses, and how strong the evidence is.
- Quality & Purity25%7.3
Third-party testing and certifications, manufacturing standards, contaminant testing, recall history.
- Value20%7.8
Cost per effective serving compared with category peers.
- Experience15%7.9
Taste, mixability, texture and tolerability from aggregated buyer and creator feedback.
- Transparency10%6.6
Full label disclosure (no proprietary blends), available COAs, honest marketing.
Our review
Qunol Ultra CoQ10 puts 100 mg of ubiquinone, the standard form of coenzyme Q10, in one softgel with 68 mg of synthetic vitamin E, suspended in MCT oil with polysorbate 80 so it disperses in water as well as fat. Qunol advertises "3X better absorption" than regular CoQ10 but does not name the study behind it. In 2009 the National Advertising Division found a reasonable basis for an "up to 300% more absorbable" claim against standard powdered CoQ10, while telling the company not to equate absorption with effectiveness; keep that in mind when the bottle says 100 mg equals 300 mg.
The bigger question is CoQ10 itself. For statin-related muscle aches, meta-analyses disagree: a 2018 analysis of 12 trials found less pain, while 2015 and 2020 analyses found no significant benefit. A 2016 Cochrane review found no clinically meaningful effect on blood pressure. In heart failure, the Q-SYMBIO trial reported fewer major cardiac events with 300 mg a day added to standard care for two years, and the best-known migraine trial also used 300 mg, so one softgel sits at the low end of studied doses.
At qunol.com, 90 softgels cost $25.99, about $0.29 a day. Buyers consistently describe it as easy to take once a day with food; complaints include the one-inch softgel, additives such as polysorbate 80 and sorbitol, melted shipments and feeling no difference, which Qunol's own FAQ calls normal. The "#1 cardiologist recommended" badge refers to water-and-fat-soluble CoQ10 in general, per a 2024 IQVIA survey. The softgel uses bovine gelatin, some listings still show an older label with soy lecithin, and CoQ10 can weaken warfarin's effect.
What’s inside
| Key ingredient | Per serving | Why it matters |
|---|---|---|
| Coenzyme Q10 (ubiquinone) Solubilized to improve absorption; the Q-SYMBIO heart-failure trial and the best-known migraine trial used 300 mg a day in three doses. | 100 mg | Solubilized to improve absorption; the Q-SYMBIO heart-failure trial and the best-known migraine trial used 300 mg a day in three doses. |
| Vitamin E (as dl-alpha tocopheryl acetate) Synthetic vitamin E, roughly 150 IU; it adds to other vitamin E sources, and high intakes can raise bleeding risk with blood thinners. | 68 mg (453% DV) | Synthetic vitamin E, roughly 150 IU; it adds to other vitamin E sources, and high intakes can raise bleeding risk with blood thinners. |
| Polysorbate 80 and medium chain triglycerides Emulsifier and oil base that make the CoQ10 water- and fat-dispersible; Qunol says polysorbate 80 is under 1% of the formula. | — | Emulsifier and oil base that make the CoQ10 water- and fat-dispersible; Qunol says polysorbate 80 is under 1% of the formula. |
Supplement Facts
Serving Size 1 Softgel
Servings Per Container 90
Amount Per Serving% Daily Value
Calories 5
Vitamin E (as dl-alpha tocopheryl acetate) 68 mg453%
Coenzyme Q10 100 mg**
* Percent Daily Values are based on a 2,000 calorie diet. † Daily Value not established.
Other ingredients: Medium chain triglycerides (palm oil), polysorbate 80, gelatin, glycerin, sorbitol, purified water, annatto suspension in sunflower oil (color).
Testing & quality
Qunol says all its products are third-party tested, with results kept confidential, and made in cGMP-compliant US facilities; no USP or NSF certification is claimed. A December 2025 Class II recall covered three lots of Qunol Extra Strength Turmeric capsules (mold in a raw material), not CoQ10.
Goals it supports
Creator video reviews
Independent creators reviewing Ultra CoQ10 100 mg Softgels on YouTube and TikTok.
2 positive0 mixed1 critical
Pros & cons
What we like
- Solubilized formula; the NAD found a reasonable basis for its higher-absorption claim versus standard powdered CoQ10
- Short, fully disclosed label: 100 mg CoQ10 plus vitamin E, no proprietary blend
- Inexpensive at about $0.29 per day from qunol.com
- Brand states third-party testing and cGMP manufacturing; labeled gluten-free
Watch-outs
- 100 mg is below the 300 mg a day used in the key heart-failure and migraine trials
- Evidence for statin muscle aches is mixed and for blood pressure is negative
- Testing results are kept confidential, and the #1 cardiologist claim rests on a survey about the form, not the brand
- Bovine gelatin, polysorbate 80 and sorbitol; some buyers find the one-inch softgel large
Questions buyers ask
Is Qunol Ultra ubiquinone or ubiquinol, and does it matter?
Ultra contains ubiquinone; Qunol's Mega line uses ubiquinol. The body converts between the two, and most CoQ10 in the blood is ubiquinol whichever form you swallow. A 2020 study in older adults found ubiquinol capsules were not significantly better absorbed than standard ubiquinone, while a solubilized formula was. Ultra's advantage comes from its solubilized base, and either form is best taken with food.
Does CoQ10 help with statin muscle pain?
The evidence is split. A 2018 meta-analysis of 12 small trials found less muscle pain, weakness and cramps, but 2015 and 2020 meta-analyses found no significant benefit, and the NIH's complementary health center says the overall evidence does not support it. Trying it is low risk with your doctor's agreement, but do not stop or change a statin on your own.
Is one 100 mg softgel enough?
It is a common supplement dose, but the most cited trials used more: 300 mg a day in the Q-SYMBIO heart-failure trial and in the best-known migraine trial. Qunol says 100 mg of Ultra equals 300 mg of regular CoQ10 based on absorption, but equal blood levels have not been shown to produce equal results. People with heart failure should use CoQ10 only with their cardiologist's guidance.
Sources we checked (31)
- 1.qunol.com/products/qunol-ultra-coq10
- 2.faqs.qunol.com/en-US/articles/coq10-product-details-and-ingredients-334827
- 3.faqs.qunol.com/en-US/articles/taking-coq10-334826
- 4.faqs.qunol.com/en-US/articles/understanding-coq10-334824
- 5.faqs.qunol.com/en-US/articles/general-product-faq-297989
- 6.qunol.com/pages/about-us
- 7.qunol.com/policies/terms-of-service
- 8.vitacost.com/products/qunol-ultra-coq10-100-mg-90-softgels-126282
- 9.walmart.com/ip/575061142
- 10.walmart.com/ip/17324916
- 11.shop.tiktok.com/us/pdp/qunol-coq10-100mg-softgels-ultra-absorption-heart-health-energ
- 12.bbbprograms.org/media/newsroom/decisions/nad-finds-quten-can-support-certain-claims-f
- 13.sanofi.com/en/media-room/press-releases/2023/2023-09-29-15-59-05-2752155
- 14.sec.gov/Archives/edgar/data/1121404/000119312525106923/d935542dex991.htm
- 15.opella.com/en/our-brands
- 16.api.fda.gov/food/enforcement.json?search=product_description:%22qunol%22
- 17.nccih.nih.gov/health/coenzyme-q10
- 18.lpi.oregonstate.edu/mic/dietary-factors/coenzyme-Q10
- 19.lpi.oregonstate.edu/mic/vitamins/vitamin-E
- 20.pubmed.ncbi.nlm.nih.gov/25440725/
- 21.pubmed.ncbi.nlm.nih.gov/30371340/
- 22.pubmed.ncbi.nlm.nih.gov/32179207/
- 23.pubmed.ncbi.nlm.nih.gov/25282031/
- 24.pubmed.ncbi.nlm.nih.gov/35608922/
- 25.pubmed.ncbi.nlm.nih.gov/26935713/
- 26.pubmed.ncbi.nlm.nih.gov/33402403/
- 27.pubmed.ncbi.nlm.nih.gov/22529203/
- 28.pubmed.ncbi.nlm.nih.gov/15728298/
- 29.pubmed.ncbi.nlm.nih.gov/32188111/
- 30.pubmed.ncbi.nlm.nih.gov/17482886/
- 31.pubmed.ncbi.nlm.nih.gov/9565826/
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